abstract：INTRODUCTION:Available data on fibrin clot properties and fibrinolysis in hyperthyroidism and hypothyroidism are inconsistent. Our objective was to assess the impact of effective treatment of hyper- and hypothyroidism on fibrin clot characteristics. MATERIAL AND METHODS:In a case-control study, ex vivo plasma fibrin c...

journal_title：Thrombosis research

authors： Mazur P,Sokołowski G,Hubalewska-Dydejczyk A,Płaczkiewicz-Jankowska E,Undas A

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:Guidelines recommend the assessment of stroke and bleeding risk before initiating warfarin anticoagulation in patients with atrial fibrillation. Many of the elements used to predict stroke also overlap with bleeding risk in atrial fibrillation patients and it is tempting to use stroke risk scores to effici...

journal_title：Thrombosis research

authors： Barnes GD,Gu X,Haymart B,Kline-Rogers E,Almany S,Kozlowski J,Besley D,Krol GD,Froehlich JB,Kaatz S

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:D-dimer, a fibrin degradation product, is related to risk of cardiovascular disease and venous thromboembolism. Genetic determinants of D-dimer are not well characterized; notably, few data have been reported for African American (AA), Asian, and Hispanic populations. MATERIALS AND METHODS:We conducted a ...

journal_title：Thrombosis research

authors： Weng LC,Tang W,Rich SS,Smith NL,Redline S,O'Donnell CJ,Basu S,Reiner AP,Delaney JA,Tracy RP,Palmer CD,Young T,Yang Q,Folsom AR,Cushman M

更新日期：2014-08-01 00:00:00

abstract：:Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), presents a large clinical burden. Prompt, effective and sustained anticoagulation is vital because of the risk of recurrent events, including life-threatening PE, and complications such as post-thrombotic syndrome and chro...

journal_title：Thrombosis research

authors： Prandoni P

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:We examined a 6-month-old girl with inherited fibrinogen abnormality and no history of bleeding or thrombosis. Routine coagulation screening tests showed a markedly low level of plasma fibrinogen determined by functional measurement and also a low level by antigenic measurement (functional/antigenic ratio=...

journal_title：Thrombosis research

authors： Ikeda M,Kobayashi T,Arai S,Mukai S,Takezawa Y,Terasawa F,Okumura N

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:To determine whether the HIT IgG class platelet factor 4 (PF4) enzyme immunoabsorbant assay (EIA) influenced the duration of parenteral direct thrombin inhibitor (pDTI) therapy or bleeding risk in patients started on pDTI for a presumed diagnosis of HIT. MATERIALS/METHODS:187 patients started on pDTI for ...

journal_title：Thrombosis research

authors： Reagan JL,Ingham RR 2nd,Dalia S,Butera JN,Sweeney JD

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:The activation of coagulation is recognized as a universal event in severe sepsis. Both antithrombin and thrombomodulin play pivotal roles as suppressors of coagulation. Since the levels of both anticoagulants decrease significantly, we hypothesized that a combination therapy would be beneficial. METHODS:...

journal_title：Thrombosis research

authors： Iba T,Miki T,Hashiguchi N,Tabe Y,Nagaoka I

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Conventional Vacutainer® Sodium Citrate blood collection tubes contain a relatively high concentration of contaminating magnesium ions, which may result in shortening of the prothrombin time (PT) and the International Normalized Ratio (INR). Recently the manufacturer of Vacutainer® Sodium Citrate tubes int...

journal_title：Thrombosis research

authors： van den Besselaar AM,van Vlodrop IJ,Berendes PB,Cobbaert CM

更新日期：2014-07-01 00:00:00

abstract：:The serotonin transporter (SERT) is found in neuron and platelet membranes. Selective serotonin-reuptake inhibitors (SSRIs) are widely prescribed for severe depression. They may at least partly counteract the effects of serotonin on the vascular biology system, can lower agonists-induced platelet activation, aggregati...

journal_title：Thrombosis research

authors： Hoirisch-Clapauch S,Nardi AE,Gris JC,Brenner B

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:It has been previously shown that platelets of patients with diabetes are more reactive and less responsive to anti-platelet drugs compared with platelets from subjects without diabetes. Studies examining the effect of glycemic control on platelet reactivity have yielded conflicting data. Thus, in this study...

journal_title：Thrombosis research

authors： Singer J,Weissler Snir A,Leshem-Lev D,Rigler M,Kornowski R,Lev EI

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Congenital factor V (FV) deficiency is a rare inherited disorder. Three compound heterozygous missense mutations, Asp68His, His147Arg, and Arg2074Cys, were observed in a Taiwanese patient with moderately severe FV deficiency. METHOD:The novel His147Arg mutation in the A1 domain was investigated by protein...

journal_title：Thrombosis research

authors： Liu HC,Lin TM,Eng HL,Lin YT,Shen MC

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:To evaluate the role of filter implantation in reducing the incidence of fatal pulmonary embolism during the endovascular treatment of thrombosis in the major tributary of the superior vena cava (SVC). METHODS:From October 2004 to October 2008, we conducted a cohort study of 40 patients with thrombosis of t...

journal_title：Thrombosis research

authors： Liang Z,Han R,Qu Y,Cao W,Cui J

更新日期：2014-07-01 00:00:00

abstract：:Low circulating protein C (PC) levels have been observed in sepsis, especially in patients with Neisseriae Meningitides infections. Poor clinical outcome and high limb amputation rates have been associated in infected patients with low circulating PC levels. Published studies using activated PC replacement therapy pat...

journal_title：Thrombosis research

authors： Piccin A,O' Marcaigh A,Mc Mahon C,Murphy C,Okafor I,Marcheselli L,Casey W,Claffey L,Smith OP

更新日期：2014-07-01 00:00:00

abstract：:Although effective therapies for haemophilia have been available for decades, the prevention and treatment of joint disease remain major clinical concerns for all haemophilia patients. Early identification of joint disease is vital to initiate or modify treatment, and prevent arthropathy. However, there remains a need...

journal_title：Thrombosis research

authors： Lambert T,Auerswald G,Benson G,Hedner U,Jiménez-Yuste V,Ljung R,Morfini M,Remor E,Santagostino E,Zupančić Šalek S

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Aging and renal impairment may prolong the half-life and lead to accumulation of low molecular weight heparins. Correct dosing is critical to prevent bleeding or thrombosis. MATERIALS AND METHODS:Open, parallel study. Healthy adult [n=13] and elderly (>65yrs) [n=12] volunteers; and subjects with mild (ClC...

journal_title：Thrombosis research

authors： Rico S,Antonijoan RM,Ballester MR,Gutierro I,Ayani I,Martinez-Gonzalez J,Borrell M,Fontcuberta J,Gich I

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Clinical parameters, biomarkers and imaging-based risk stratification are widely accepted in pulmonary embolism(PE). The present study has investigated the prognostic role of simplified Pulmonary Embolism Severity Index (sPESI) score and the European Society of Cardiology (ESC) model. METHODS:This prospecti...

journal_title：Thrombosis research

authors： Ozsu S,Ozlu T,Sentürk A,Uçar EY,Kırkıl G,Kadıoğlu EE,Altınsoy B,Saylan B,Selimoğlu HŞ,Dabak G,Tutar N,Uysal A,TUPEG Study Investigators.

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Integrin αIIbβ3 mediates platelet adhesion, aggregation and fibrin clot retraction. These processes require activation of αIIbβ3 and post-ligation signaling. Disulfide bond exchanges are involved in αIIbβ3 and αvβ3 activation. METHODS:In order to investigate the role of integrin activation and disulfide bon...

journal_title：Thrombosis research

authors： Mor-Cohen R,Rosenberg N,Averbukh Y,Seligsohn U,Lahav J

更新日期：2014-05-01 00:00:00

abstract：:Since the 19(th) century an association between cancer and thromboembolic events has been described, with a poorer survival prognosis. Production and secretion of procoagulant factors affect tumor biology and cancer-associated thrombosis. Tissue factor (TF) exerts coagulant and protease activated receptor (PAR)-depend...

journal_title：Thrombosis research

authors： Ünlü B,Versteeg HH

更新日期：2014-05-01 00:00:00

abstract：:Clinically unsuspected pulmonary embolism (UPE) is frequently diagnosed in cancer patients undergoing routine computed tomography scans for staging purposes or treatment response evaluation. The reported incidence of UPE ranges from 1% to 5% which probably represents an underestimation. A significant proportion of can...

journal_title：Thrombosis research

authors： van Es N,Bleker SM,Di Nisio M

更新日期：2014-05-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) has become the most curable form of acute myeloid leukemia after the advent of all-trans retinoic acid (ATRA). However, early deaths (ED) mostly due to the disease-associated coagulopathy remain the major cause of treatment failure. In particular, hemorrhagic events account for 40-65...

journal_title：Thrombosis research

authors： Breccia M,Lo Coco F

更新日期：2014-05-01 00:00:00

abstract：:Deep vein thrombosis and pulmonary embolism, collectively termed venous thromboembolism (VTE), affect over 1 million Americans each year. VTE is triggered by inflammation and blood stasis leading to the formation of thrombi rich in fibrin and red blood cells (RBCs). However, little is known about mechanisms regulating...

journal_title：Thrombosis research

authors： Aleman MM,Walton BL,Byrnes JR,Wolberg AS

更新日期：2014-05-01 00:00:00

abstract：:Initiation of clotting cascade by tissue factor (TF): Factor VII (FVII) complex is essential for hemostasis however pathologic expression of TF leads to thrombosis. In contrast, the contact pathway factor XII, and to the smaller extent FXI are dispensable for normal hemostasis but still contribute to pathologic thromb...

journal_title：Thrombosis research

authors： Hoffman M,Pawlinski R

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:The recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) is undergoing clinical trials for prophylaxis and on-demand treatment of haemophilia B patients. The aim of this study was to investigate the pharmacokinetics, whole-body and knee joint distribution of rIX-FP following intra...

journal_title：Thrombosis research

authors： Herzog E,Harris S,Henson C,McEwen A,Schenk S,Nolte MW,Pragst I,Dickneite G,Schulte S,Zollner S

更新日期：2014-05-01 00:00:00

abstract：:Several single-nucleotide polymorphisms (SNPs) have been recognized as associated with ischemic heart disease (IHD) although the optimal set of risk genotypes has not be identified. This study aimed to examine whether identified high-risk SNPs are associated with early onset of IHD. In the GENOCOR study, 44 high-risk ...

journal_title：Thrombosis research

authors： Vecoli C,Adlerstein D,Shehi E,Bigazzi F,Sampietro T,Foffa I,Carpeggiani C,L'abbate A,Andreassi MG

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Previous studies have suggested the used of off-label recombinant factor VII (rFVIIa) increases the risk of thromboembolic events, but the effect of the dose of rFVIIa is not well described in the literature. MATERIALS AND METHODS:All adult patients that received off-label rFVIIa from 2005-2012 were inclu...

journal_title：Thrombosis research

authors： Bucklin MH,Acquisto NM,Nelson C

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:The present cohort study was performed to investigate the impact of the factor 5 rs6025 [F5] and the factor 2 rs1799963 [F2] mutations on high-titer inhibitor development [HRI] in patients with severe/moderate-severe hemophilia A [HA]. PATIENTS AND METHODS:216 patients with F8<2% born between 1980 and 2011 w...

journal_title：Thrombosis research

authors： Kenet G,Bidlingmaier C,Bogdanova N,Ettingshausen CE,Goldenberg N,Gutsche S,Halimeh S,Holzhauer S,Kurnik K,Limperger V,Junker R,Nowak-Göttl U

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Patients with multiple myeloma (MM) have an increased risk of thromboembolic events (TEE). Due to the complex nature of the prothrombotic state in MM, no single laboratory test has been designed to identify patients with the highest risk of developing TEE. Hence, this study is intended to assess the feasib...

journal_title：Thrombosis research

authors： Treliński J,Misiewicz M,Robak M,Smolewski P,Chojnowski K

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Genetic and autoimmune risk factors contribute to the development of thrombotic thrombocytopenic purpura (TTP) but triggers are needed to bring about acute disease. The aim of the study was to investigate the association of neutrophil activation with acute TTP, to assess whether neutrophil activation chang...

journal_title：Thrombosis research

authors： Mikes B,Sinkovits G,Farkas P,Csuka D,Schlammadinger A,Rázsó K,Demeter J,Domján G,Réti M,Prohászka Z

更新日期：2014-04-01 00:00:00

abstract：:While the role of platelets in hemostasis is well characterized from a biological perspective, the biophysical interactions between platelets and their mechanical microenvironment are relatively unstudied. The field of cellular mechanics has developed a number of approaches to study the effects of extracellular matrix...

journal_title：Thrombosis research

authors： Ciciliano JC,Tran R,Sakurai Y,Lam WA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Histamine is classified as an inflammatory mediator and has been reported to have anti- as well as pro-inflammatory properties. The aim of this study was to explore the role of histamine on the production of LPS-induced tissue factor (TF) activity and TNFα in monocytes of whole blood in the absence and prese...

journal_title：Thrombosis research

authors： Østerud B,Olsen JO

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Warfarin is the most widely prescribed vitamin K antagonist and in the United States and Europe more than 10 million people are currently in long-term oral anticoagulant treatment. This study aims to retrospectively validate a dynamic statistical model providing dosage suggestions to patients in warfarin t...

journal_title：Thrombosis research

authors： Nielsen PB,Lundbye-Christensen S,Rasmussen LH,Larsen TB

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:According to US Food and Drugs Administration (FDA), 2 hour recombinant tissue plasminogen activator (rt-PA) 100mg infusion is recommended for eligible patients with acute pulmonary embolism (PE). However,there exists evidence implying that a lower dosage of rt-PA can be equally effective but p...

journal_title：Thrombosis research

authors： Zhang Z,Zhai ZG,Liang LR,Liu FF,Yang YH,Wang C

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:In the treatment of bleeds in haemophilia patients with inhibitors, a high initial dose of recombinant Factor VIIa (rFVIIa) provides at least equal efficacy and a similar safety profile to a standard initial dose. However, no pharmacoeconomic comparison between these dosing regimens has previously been per...

journal_title：Thrombosis research

authors： Salaj P,Kubes R,Cetkovsky P,Capova I,Penka M,Ovesná P,Mesterton J,Lindgren P

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Circulating microparticles support thrombin generation. The aim of this study is to determine the indirect microparticle activity and the parameters of thrombin generation in healthy infants. MATERIALS AND METHODS:A total of 85 infants who were brought to follow-up visits were taken into the study. Blood ...

journal_title：Thrombosis research

authors： Orhon FS,Egin Y,Ulukol B,Baskan S,Akar N

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Vitamin K antagonists are often used for anticoagulant treatment in hip fracture patients. The optimal handling with such anticoagulants is unclear. We aimed to determine when anticoagulation reversal occurred after vitamin K administration and how often prothrombin complex concentrates (PCCs) were adminis...

journal_title：Thrombosis research

authors： Buecking B,Eschbach D,Bliemel C,Oberkircher L,Struewer J,Ruchholtz S,Sachs UJ

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Medically ill, hospitalized patients are at increased risk for venous thromboembolism (VTE) after discharge. This study aimed to examine thromboprophylaxis patterns, risk factors, and post-discharge outcomes. METHODS:This was a retrospective claims analysis involving administrative claims data and in-pati...

journal_title：Thrombosis research

authors： Mahan CE,Fisher MD,Mills RM,Fields LE,Stephenson JJ,Fu AC,Spyropoulos AC

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:Venous thromboembolism is a common cause of morbidity and mortality. Although cirrhosis has classically been considered as an acquired bleeding diathesis, there is increasing evidence that rejects the traditional belief that these patients are naturally protected against venous thromboembolism. However, an...

journal_title：Thrombosis research

authors： Gómez Cuervo C,Bisbal Pardo O,Pérez-Jacoiste Asín MA

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:The contribution of platelet activation to the pathogenesis of sickle cell disease (SCD) remains uncertain. We evaluated the safety and efficacy of eptifibatide, a synthetic peptide inhibitor of the αIIbβ3 receptor, in SCD patients during acute painful episodes. MATERIALS AND METHODS:In this single site, ...

journal_title：Thrombosis research

authors： Desai PC,Brittain JE,Jones SK,McDonald A,Wilson DR,Dominik R,Key NS,Parise LV,Ataga KI

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Antithrombin (AT), protein C (PC) and protein S (PS) deficiencies are risk factors for venous thromboembolism. Overlapping values between heterozygous carriers and normal individuals often make a correct classification of a deficiency difficult. The aim of this study was to investigate the effect of sex, a...

journal_title：Thrombosis research

authors： Franchi F,Biguzzi E,Martinelli I,Bucciarelli P,Palmucci C,D'Agostino S,Peyvandi F

更新日期：2013-08-01 00:00:00

abstract：:Postoperative chylothorax is a frequently encountered pathology occurring in up to 4% of patients undergoing surgery for repair of congenital heart disease. Symptomatic thrombosis is associated with chylothorax and may contribute to its severity and duration. Furthermore, vessel thrombosis resulting in persistent vess...

journal_title：Thrombosis research

authors： Bauman ME,Moher C,Bruce AK,Kuhle S,Kaur S,Massicotte MP

更新日期：2013-08-01 00:00:00